Glibenclamide (GBM) is an oral hypoglycemic agent belonging to the second generation of sulfonylurea’s commonly employed in the treatment of type II non insulin-dependent diabetes. Its hypoglycemic effect is mainly due to stimulation of insulin release from pancreatic beta cells and sensitization of the peripheral tissues to insulin. GBM is highly lipophilic and minimally soluble in aqueous media. Guar gum has gained immense importance because of its constructive role of releasing sugars and absorbing sugars slowly in the intestinal tract; consequently, reduce the severity of diabetes mellitus and also act as a prospective hydrophilic matrix carrier for oral controlled delivery of drugs. In this study, an approach to possible physical interaction between Glibenclamide and guar gum is presented. For the investigative purpose; molecular level property, particulate level property and thermal methods of analysis have been assessed. Results of FTIR, PXRD, DSC and TGA studies indicated that Guar gum had compatibility with Glibenclamide.
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